Acyl hydrazides as peptoid sub-monomers.
نویسندگان
چکیده
The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry.
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عنوان ژورنال:
- Chemical communications
دوره 47 38 شماره
صفحات -
تاریخ انتشار 2011